Buffalo Bills vs. San Francisco 49ers predictions, picks, and game preview for Week 13 of the 2020 NFL season. Buffalo Bills vs San Francisco 49ers prediction, game preview, and fantasy player to watch. Buffalo Bills vs San Francisco 49ers Broadcast Date: Sunday, December 7 Game Time: 8:15 ET Venue: State. These are four bold predictions for the Buffalo Bills against the San Francisco 49ers. The last time the Buffalo Bills were on Monday Night Football was th.

1. Bills 49ers Prediction Odds
2. Bills 49ers Prediction Seahawks

Buffalo Bills vs San Francisco 49ers prediction, game preview, and fantasy player to watch.

Bills 49ers Prediction Odds

Buffalo Bills vs San Francisco 49ers Broadcast

Date: Sunday, December 7
Game Time: 8:15 ET
Venue: State Farm Stadium, Glendale, AZ
Network: ESPN and ABC

– All of the CFN Fearless Predictions

Buffalo Bills (8-3) vs San Francisco 49ers (5-6) Game Preview

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Why Buffalo Bills Will Win

Bills 49ers Prediction Seahawks

Buffalo has to start running, keep running, and don’t stop pounding.

There’s a turnover issue – more on that in a moment – and the offense works best when Josh Allen is balancing things out with his big shots down the field, but the San Francisco secondary is getting strong again, it’s fourth in the NFL in pass D, and it’s coming off a game when it made Jared Goff of the Rams look silly.

The Bills are 5-0 when running for over 100 yards, and control in this will matter. The Rams had some success on the ground, even if most of it came from one Cam Akers run. However …

– CFN Experts Picks: NFL

Why San Francisco 49ers Will Win

Buffalo can’t give the ball away.

San Francisco is too inconsistent with its big defensive plays, but when it makes them happen, forget it.

New England was able to run wild on the Niners, and lost big because of four turnovers. The same went for the Giants, who also ran well but lost big because of three giveaways. Last week? The Rams turned it over four times.

Buffalo has turned it over at least once in every game but two, and it screwed up five times over the last two games – losing to Arizona and beating the Chargers – with mistakes.

Fantasy Football Player To Watch

RB Zack Moss, Buffalo
Can the Bills get steady production out of any of its backs? Devin Singletary has been fine at times, and Josh Allen is the most dangerous runner, but Moss has the best overall pop – now he needs the work. He ran for three touchdowns over a two-game stretch after coming off an injury, but that was it. He’ll get the ball around the goal line, but in this, feed him 15 times and watch what happens.

What’s Going To Happen

Yeah, Buffalo has had a turnover problem at times, but San Francisco has a bigger one with 13 over the last five games. The defense was able to pick up the slack against the Rams, but that won’t happen this week.

A “home” game for San Francisco in name only, it’s being played in Arizona, it’ll have a strange feel, and Buffalo will come out physical from the start as it runs for 150 yards, dominates on third downs, and is a +2 in turnover margin.

Buffalo Bills vs San Francisco 49ers Prediction, Line

Buffalo 27, San Francisco 24
Bet on Buffalo vs San Francisco with BetMGM
San Francisco -1, o/u: 47
ATS Confidence out of 5: 2.5

Must See Rating: 3.5

5: Gangs of London
1: Hillbilly Elegy

Game: Buffalo Bills vs San Francisco 49ers

Date: Monday, December 7, 2020

Location: State Farm Stadium in Glendale, AZ

TV: ESPN

Odds/Point Spread: San Francisco +2.5

Total/Over-Under: 48

Nick Mullens and the San Francisco 49ers (5-6) host the Buffalo Bills (8-3) at State Farm Stadium on Monday, December 7, 2020. San Francisco opens this game as 2.5-point dogs. The over/under opens at 48.

The Buffalo Bills come into this matchup with a record of 8-3 for this season. In their last game they faced the Los Angeles Chargers and earned the victory by a score of 27-17. Josh Allen went 18/24 with 157 yards passing and added 1 touchdown. He tossed 1 pick during the game. Devin Singletary led the team in rushing for the game. He had a long run of 24 yards but wasn't able to convert a rushing touchdown. He ran for a total of 82 yards by way of 11 carries which had him averaging 7.5 yards per run. Gabriel Davis was the leader in receiving yardage with a tally of 79 yards on 3 catches. He earned an average of 26.3 yards per catch for the game. The Buffalo Bills ran the ball 30 times and racked up 172 yards earning them an average of 5.7 yards per rush. In the game, they ran 58 plays for a total of 332 yards. For the game, the Bills totaled 23 1st downs and they had 9 penalties for 85 yards. In terms of defense, Buffalo allowed 31 catches on 52 tries totaling 291 yards, and a completion percentage of 60.0%. Against the run, the Bills allowed 76 yards on 24 carries which is an average of 3.2 yards per attempt allowed. For the game, they gave up 367 yards and earned 1 turnover.

The Bills currently have 4,097 yards in total over the course of this season. As a team they're holding an average of 104.4 yards on the ground ranking this team at 22nd in the National Football League. When it comes to scoring, Buffalo has amassed 24 touchdowns through the air and 10 touchdowns on the ground. Regarding scoring, the Buffalo Bills have an average of 27.2 points per contest. Concerning passing yards, the Bills have conceded 2,678 yards which ranks them 18th in the NFL. For the season, they have relinquished 373.1 yards per contest which has them ranked 21st in the league. The Bills sit in 18th in the league in relation to their opponents scoring, allowing 25.6 PPG. They are giving up 4.7 yards per run and 129.6 rushing yards per contest this season. Over the course of their 11 games played, they have surrendered 243.5 yards per contest via the pass as well as allowing a completion percentage of 66.8%. During this campaign, they have given up 1,426 rushing yards through 11 outings.

The 49ers head into this matchup 5-6 for this season. In their last contest they played the Los Angeles Rams and won by a score of 23-20. Raheem Mostert paced the team in rushing for the game. He tore off a long run of 10 yards and he added 1 TD for the game. He scurried for 43 yards on 16 carries which meant he averaged 2.7 yards per run. Deebo Samuel led the team in receiving yardage with a total of 133 yards on 11 receptions. He had an average of 12.1 yards per catch for the game. Nick Mullens went 24/35 with 252 yards through the air but wasn't able to get any balls in the endzone via the pass. He gave away 1 interception in the game. The San Francisco 49ers ran the ball 33 times and earned 115 yards which had them averaging 3.5 yards per carry. On the day, the 49ers racked up a total of 18 first downs and they totaled 5 penalties for 40 yards. In all, they ran 70 plays for a total of 348 yards. When discussing the defense, San Francisco allowed 19 catches on 31 throws for a total of 182 yards, and a completion percentage of 61.0%. On the day, they conceded a total of 308 yards and forced 4 takeaways. On the ground, the 49ers allowed 126 yards on 28 tries which is an average of 4.5 yards per attempt allowed.

For the season so far, the 49ers have earned 2,760 passing yards as well as holding an average of 250.9 passing yards per contest, which is ranked 12th in football. The San Francisco 49ers have an average of 363.2 yards per contest ranking them 14th out of all teams in the league. They hold an average of 112.3 rushing yards per game and have rushed for 1,235 yards in total. In terms of this team's ability to score points, the 49ers are ranked 20th in the league scoring 23.7 PPG. The 49ers are sitting in 11th in the NFL when it comes to team defense, giving up 23.1 PPG. They are giving up 4.0 yards per rushing attempt and 108.7 rushing yards per contest this season. Over the course of this season, they have conceded 1,196 yards on the ground through 11 contests. When it comes to yards via the pass, the 49ers have given up 2,271 yards which ranks them 5th in football. In their 11 games played this year, they are giving up 206.5 yards per contest via the pass in addition to conceding a completion percentage of 64.6%. Overall, they are allowing 315.2 yards/outing ranking them 6th in the National Football League.

Who will win tonight's Bills/49ers NFL game against the spread?

Tony's Pick: Take the Bills -2.5

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